| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50156858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_429751 (CHEMBL914451) |
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| IC50 | 150±n/a nM |
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| Citation |  Fonquerna, S; Miralpeix, M; Pagès, L; Puig, C; Cardús, A; Antón, F; Cárdenas, A; Vilella, D; Aparici, M; Calaf, E; Prieto, J; Gras, J; Huerta, JM; Warrellow, G; Beleta, J; Ryder, H Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives. J Med Chem47:6326-37 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50156858 |
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| n/a |
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| Name | BDBM50156858 |
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| Synonyms: | 3-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}benzoic acid | CHEMBL222142 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27FN2O3 |
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| Mol. Mass. | 410.4812 |
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| SMILES | COCCn1cc(C2CCN(Cc3cccc(c3)C(O)=O)CC2)c2ccc(F)cc12 |
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| Structure | 
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