Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHistamine H2 Receptor
LigandBDBM50156861
Substrate/Competitorn/a
Meas. Tech.ChEMBL_429753
IC50 1025±n/a nM
Citation Fonquerna SMiralpeix MPagès LPuig CCardús AAntón FCárdenas AVilella DAparici MCalaf EPrieto JGras JHuerta JMWarrellow GBeleta JRyder H Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives. J Med Chem 47:6326-37 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 Receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40115.31
Organism:Homo sapiens (Human)
Description:n/a
Residue:359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50156861
n/a
NameBDBM50156861
Synonyms:2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluoro-1H-indol-3-yl)piperidin-1-yl)ethoxy)benzoic acid | CHEMBL374459
TypeSmall organic molecule
Emp. Form.C27H26ClFN2O3S
Mol. Mass.513.023
SMILESOC(=O)c1ccccc1OCCN1CCC(CC1)c1cn(Cc2ccc(Cl)s2)c2cc(F)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: