| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM50157098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302558 (CHEMBL839521) |
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| Ki | 640±n/a nM |
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| Citation |  Bruncko, M; McClellan, WJ; Wendt, MD; Sauer, DR; Geyer, A; Dalton, CR; Kaminski, MA; Weitzberg, M; Gong, J; Dellaria, JF; Mantei, R; Zhao, X; Nienaber, VL; Stewart, K; Klinghofer, V; Bouska, J; Rockway, TW; Giranda, VL Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett15:93-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM50157098 |
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| n/a |
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| Name | BDBM50157098 |
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| Synonyms: | 6-[2-((S)-1-Isopropyl-3,4-dihydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL183021 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N3 |
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| Mol. Mass. | 381.5127 |
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| SMILES | CC(C)C1=NCCc2ccc(cc12)[C@H]1CC1c1ccc2cc(ccc2c1)C(N)=N |t:3| |
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| Structure | 
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