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TargetUrokinase-type plasminogen activator
LigandBDBM50157095
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302922 (CHEMBL830381)
Ki 380±n/a nM
Citation Bruncko, MMcClellan, WJWendt, MDSauer, DRGeyer, ADalton, CRKaminski, MAWeitzberg, MGong, JDellaria, JFMantei, RZhao, XNienaber, VLStewart, KKlinghofer, VBouska, JRockway, TWGiranda, VL Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett15:93-8 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urokinase-type plasminogen activator
Name:Urokinase-type plasminogen activator
Synonyms:PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:Enzyme
Mol. Mass.:48528.62
Organism:Homo sapiens (Human)
Description:P00749
Residue:431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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  Blast E-value cutoff:
BDBM50157095
n/a
NameBDBM50157095
Synonyms:6-[2-((R)-1-Isopropyl-3,4-dihydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL182065
TypeSmall organic molecule
Emp. Form.C26H27N3
Mol. Mass.381.5127
SMILESCC(C)C1=NCCc2ccc(cc12)[C@@H]1CC1c1ccc2cc(ccc2c1)C(N)=N |t:3|
Structure
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