Reaction Details |
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Target | Urokinase-type plasminogen activator |
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Ligand | BDBM50157095 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302922 (CHEMBL830381) |
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Ki | 380±n/a nM |
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Citation | Bruncko, M; McClellan, WJ; Wendt, MD; Sauer, DR; Geyer, A; Dalton, CR; Kaminski, MA; Weitzberg, M; Gong, J; Dellaria, JF; Mantei, R; Zhao, X; Nienaber, VL; Stewart, K; Klinghofer, V; Bouska, J; Rockway, TW; Giranda, VL Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett15:93-8 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Urokinase-type plasminogen activator |
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Name: | Urokinase-type plasminogen activator |
Synonyms: | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor |
Type: | Enzyme |
Mol. Mass.: | 48528.62 |
Organism: | Homo sapiens (Human) |
Description: | P00749 |
Residue: | 431 |
Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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BDBM50157095 |
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n/a |
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Name | BDBM50157095 |
Synonyms: | 6-[2-((R)-1-Isopropyl-3,4-dihydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL182065 |
Type | Small organic molecule |
Emp. Form. | C26H27N3 |
Mol. Mass. | 381.5127 |
SMILES | CC(C)C1=NCCc2ccc(cc12)[C@@H]1CC1c1ccc2cc(ccc2c1)C(N)=N |t:3| |
Structure |
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