| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50157704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430105 (CHEMBL919583) |
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| IC50 | >75000±n/a nM |
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| Citation |  Llinàs-Brunet, M; Bailey, MD; Ghiro, E; Gorys, V; Halmos, T; Poirier, M; Rancourt, J; Goudreau, N A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: discovery of potent and specific tripeptide inhibitors. J Med Chem47:6584-94 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50157704 |
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| n/a |
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| Name | BDBM50157704 |
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| Synonyms: | (1R,2S)-1-((3R,5S)-1-((S)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoyl)-3-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-5-carboxamido)-2-vinylcyclopropanecarboxylic acid | CHEMBL222385 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H46N4O8 |
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| Mol. Mass. | 686.7938 |
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| SMILES | COc1ccc2c(O[C@@H]3C[C@H](N(C3)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)N[C@@]3(C[C@H]3C=C)C(O)=O)cc(nc2c1)-c1ccccc1 |r| |
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| Structure | 
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