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TargetDNA excision repair protein ERCC-5
LigandBDBM50157829
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305129 (CHEMBL832425)
IC50 0.276±n/a nM
Citation Tumey, LNBom, DHuck, BGleason, EWang, JSilver, DBrunden, KBoozer, SRundlett, SSherf, BMurphy, SDent, TLeventhal, CBailey, AHarrington, JBennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett15:277-81 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA excision repair protein ERCC-5
Name:DNA excision repair protein ERCC-5
Synonyms:ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC
Type:PROTEIN
Mol. Mass.:133069.11
Organism:Homo sapiens (Human)
Description:ChEMBL_305129
Residue:1186
Sequence:
MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50157829
n/a
NameBDBM50157829
Synonyms:3-Hydroxy-7-phenyl-1H-furo[3,2-d]pyrimidine-2,4-dione | CHEMBL183539
TypeSmall organic molecule
Emp. Form.C12H8N2O4
Mol. Mass.244.2029
SMILESOn1c(=O)[nH]c2c(coc2c1=O)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: