| Reaction Details |
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 | Report a problem with these data |
| Target | DNA excision repair protein ERCC-5 |
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| Ligand | BDBM50157833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305129 (CHEMBL832425) |
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| IC50 | 0.556±n/a nM |
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| Citation |  Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett15:277-81 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA excision repair protein ERCC-5 |
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| Name: | DNA excision repair protein ERCC-5 |
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| Synonyms: | ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 133069.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_305129 |
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| Residue: | 1186 |
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| Sequence: | MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
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| BDBM50157833 |
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| n/a |
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| Name | BDBM50157833 |
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| Synonyms: | CHEMBL182077 | N-[3''-(3-Hydroxy-2,4-dioxo-3,4-dihydro-2H-thieno[3,2-d]pyrimidin-1-ylmethyl)-biphenyl-3-yl]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N3O4S |
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| Mol. Mass. | 407.442 |
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| SMILES | CC(=O)Nc1cccc(c1)-c1cccc(Cn2c3ccsc3c(=O)n(O)c2=O)c1 |
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| Structure | 
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