Reaction Details |
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Target | Flap endonuclease 1 |
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Ligand | BDBM50157839 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304960 (CHEMBL827838) |
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IC50 | 0.035±n/a nM |
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Citation | Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett15:277-81 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Flap endonuclease 1 |
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Name: | Flap endonuclease 1 |
Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
Type: | PROTEIN |
Mol. Mass.: | 42602.57 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1517026 |
Residue: | 380 |
Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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BDBM50157839 |
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n/a |
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Name | BDBM50157839 |
Synonyms: | 3-Hydroxy-1-(4-methoxy-phenyl)-5-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL362205 |
Type | Small organic molecule |
Emp. Form. | C14H12N2O4S |
Mol. Mass. | 304.321 |
SMILES | COc1ccc(cc1)-n1c2scc(C)c2c(=O)n(O)c1=O |
Structure |
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