| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Flap endonuclease 1 |
|---|
| Ligand | BDBM50157840 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304960 (CHEMBL827838) |
|---|
| IC50 | 0.011±n/a nM |
|---|
| Citation |  Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett15:277-81 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Flap endonuclease 1 |
|---|
| Name: | Flap endonuclease 1 |
|---|
| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42602.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1517026 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
|
|
|
|---|
| BDBM50157840 |
|---|
| n/a |
|---|
| Name | BDBM50157840 |
|---|
| Synonyms: | 1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1) | 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione | CHEMBL361546 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12N2O5S |
|---|
| Mol. Mass. | 332.331 |
|---|
| SMILES | On1c(=O)n(CC2COc3ccccc3O2)c2ccsc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
