Ki Summary

Reaction Details

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Target

Potassium voltage-gated channel subfamily A member 3

Ligand

BDBM50158230

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_312032 (CHEMBL834727)

IC50

35±n/a nM

Citation

Bao, J; Miao, S; Kayser, F; Kotliar, AJ; Baker, RK; Doss, GA; Felix, JP; Bugianesi, RM; Slaughter, RS; Kaczorowski, GJ; Garcia, ML; Ha, SN; Castonguay, L; Koo, GC; Shah, K; Springer, MS; Staruch, MJ; Parsons, WH; Rupprecht, KM Potent Kv1.3 inhibitors from correolide-modification of the C18 position. Bioorg Med Chem Lett15:447-51 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Potassium voltage-gated channel subfamily A member 3

Name:

Potassium voltage-gated channel subfamily A member 3

Synonyms:

Type:

PROTEIN

Mol. Mass.:

63835.47

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1513935

Residue:

575

Sequence:

MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

BDBM50158230

n/a

Name

BDBM50158230

Synonyms:

CHEMBL362199 | Correloid derivative

Type

Small organic molecule

Emp. Form.

C39H52O16

Mol. Mass.

776.8206

SMILES

COC(=O)C12O[C@@H]1C(=O)CC1(O)C3CC[C@@]4(C)C5C=CCOC[C@]5([C@@H](C)OC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)C4[C@@]3(C)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]21C |c:19|

Structure