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TargetGlycogen phosphorylase, liver form
LigandBDBM50158307
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304931 (CHEMBL826961)
IC50 210±n/a nM
Citation Wright, SWRath, VLGenereux, PEHageman, DLLevy, CBMcClure, LDMcCoid, SCMcPherson, RKSchelhorn, TMWilder, DEZavadoski, WJGibbs, EMTreadway, JL 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg Med Chem Lett15:459-65 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen phosphorylase, liver form
Name:Glycogen phosphorylase, liver form
Synonyms:Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:Homodimer
Mol. Mass.:97153.98
Organism:Homo sapiens (Human)
Description:Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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BDBM50158307
n/a
NameBDBM50158307
Synonyms:5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl-(3-hydroxy-1-methyl-propyl)-carbamoyl]-methyl}-amide | CHEMBL178288
TypeSmall organic molecule
Emp. Form.C20H26ClN3O3
Mol. Mass.391.892
SMILESCC(CCO)N(C1CCCC1)C(=O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1
Structure
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