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TargetSphingosine 1-phosphate receptor 4
LigandBDBM50158343
Substrate/Competitorn/a
Meas. Tech.ChEMBL_430296 (CHEMBL913922)
IC50 2500±n/a nM
Citation Hale, JJLynch, CLNeway, WMills, SGHajdu, RKeohane, CARosenbach, MJMilligan, JAShei, GJParent, SAChrebet, GBergstrom, JCard, DFerrer, MHodder, PStrulovici, BRosen, HMandala, S A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J Med Chem47:6662-5 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 4
Name:Sphingosine 1-phosphate receptor 4
Synonyms:EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41647.39
Organism:Homo sapiens (Human)
Description:n/a
Residue:384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI
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  Blast E-value cutoff:
BDBM50158343
n/a
NameBDBM50158343
Synonyms:1-(4-nonylbenzyl)pyrrolidine-3-carboxylic acid | CHEMBL224703
TypeSmall organic molecule
Emp. Form.C21H33NO2
Mol. Mass.331.4922
SMILESCCCCCCCCCc1ccc(CN2CCC(C2)C(O)=O)cc1
Structure
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