Reaction Details |
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Target | Retinoic acid receptor beta |
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Ligand | BDBM50158413 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_430405 (CHEMBL916389) |
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IC50 | 90000±n/a nM |
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Citation | Patel, JB; Huynh, CK; Handratta, VD; Gediya, LK; Brodie, AM; Goloubeva, OG; Clement, OO; Nanne, IP; Soprano, DR; Njar, VC Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. J Med Chem47:6716-29 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor beta |
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Name: | Retinoic acid receptor beta |
Synonyms: | HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50498.70 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1458015 |
Residue: | 455 |
Sequence: | MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPAT
IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM
TAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIV
EFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK
IYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH
EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
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BDBM50158413 |
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n/a |
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Name | BDBM50158413 |
Synonyms: | CHEMBL388283 | N-(1H-1,2,4-triazol-1-yl)-(E)-retinamide |
Type | Small organic molecule |
Emp. Form. | C22H29N3O |
Mol. Mass. | 351.4852 |
SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=CC(C)=CC(=O)n1cncn1 |w:14.14,18.19,c:4| |
Structure |
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