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TargetRetinoic acid receptor beta
LigandBDBM50158413
Substrate/Competitorn/a
Meas. Tech.ChEMBL_430405 (CHEMBL916389)
IC50 90000±n/a nM
Citation Patel, JBHuynh, CKHandratta, VDGediya, LKBrodie, AMGoloubeva, OGClement, OONanne, IPSoprano, DRNjar, VC Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. J Med Chem47:6716-29 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Retinoic acid receptor beta
Name:Retinoic acid receptor beta
Synonyms:HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:PROTEIN
Mol. Mass.:50498.70
Organism:Homo sapiens (Human)
Description:ChEMBL_1458015
Residue:455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPAT
IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM
TAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIV
EFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK
IYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH
EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
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  Blast E-value cutoff:
BDBM50158413
n/a
NameBDBM50158413
Synonyms:CHEMBL388283 | N-(1H-1,2,4-triazol-1-yl)-(E)-retinamide
TypeSmall organic molecule
Emp. Form.C22H29N3O
Mol. Mass.351.4852
SMILESC\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=CC(C)=CC(=O)n1cncn1 |w:14.14,18.19,c:4|
Structure
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