| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50158571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430663 (CHEMBL919631) |
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| Ki | 2.1±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Wright, JE Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem47:6958-63 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50158571 |
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| n/a |
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| Name | BDBM50158571 |
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| Synonyms: | 2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-methyl-amino]-2,3-dihydro-1-oxo-2(1H)-isoindollyl]glutaric acid | CHEMBL224946 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N8O5 |
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| Mol. Mass. | 466.45 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc2C(=O)N(Cc2c1)[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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