Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50159074 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303755 (CHEMBL829798) |
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Ki | 4.639±n/a nM |
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Citation | Trapani, G; Laquintana, V; Denora, N; Trapani, A; Lopedota, A; Latrofa, A; Franco, M; Serra, M; Pisu, MG; Floris, I; Sanna, E; Biggio, G; Liso, G Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands. J Med Chem48:292-305 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50159074 |
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n/a |
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Name | BDBM50159074 |
Synonyms: | CHEMBL178705 | N,N-Dibutyl-2-[8-chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide |
Type | Small organic molecule |
Emp. Form. | C23H27Cl2N3O |
Mol. Mass. | 432.386 |
SMILES | CCCCN(CCCC)C(=O)Cc1c(nc2c(Cl)cccn12)-c1ccc(Cl)cc1 |
Structure |
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