| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50159685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302850 (CHEMBL828766) |
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| Ki | 0.15±n/a nM |
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| Citation |  Li, T; Fujita, Y; Tsuda, Y; Miyazaki, A; Ambo, A; Sasaki, Y; Jinsmaa, Y; Bryant, SD; Lazarus, LH; Okada, Y Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2. J Med Chem48:586-92 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50159685 |
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| n/a |
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| Name | BDBM50159685 |
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| Synonyms: | 5N-[1-[1-carbamoyl-2-phenyl-(1S)-ethylcarbamoyl]-2-phenyl-(1S)-ethyl]-1-[2-amino-3-(4-hydroxy-2,5-dimethylphenyl)-(2S)-propanoyl]-(5S)-dihydro-1H-5-pyrrolecarboxamide | CHEMBL367635 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H41N5O5 |
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| Mol. Mass. | 599.7198 |
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| SMILES | Cc1cc(C[C@H](N)C(=O)N2CCCC2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(C)cc1O |
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| Structure | 
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