| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50159904 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303722 (CHEMBL829057) |
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| Ki | 12±n/a nM |
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| Citation |  Palin, R; Barn, DR; Clark, JK; Cottney, JE; Cowley, PM; Crockatt, M; Evans, L; Feilden, H; Goodwin, RR; Griekspoor, F; Grove, SJ; Houghton, AK; Jones, PS; Morphy, RJ; Smith, AR; Sundaram, H; Vrolijk, D; Weston, MA; Wishart, G; Wren, P Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists. Bioorg Med Chem Lett15:589-93 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40702.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41146 |
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| Residue: | 370 |
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| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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| BDBM50159904 |
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| n/a |
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| Name | BDBM50159904 |
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| Synonyms: | 1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-hydroxy-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one | CHEMBL424971 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34ClN3O3 |
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| Mol. Mass. | 484.03 |
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| SMILES | Cc1ccc(Cl)c(OC2(CCCCC2)C(O)CN2CCC(CC2)n2c3ccccc3[nH]c2=O)c1 |
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| Structure | 
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