Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM50159916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303722 (CHEMBL829057) |
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Ki | 42±n/a nM |
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Citation | Palin, R; Barn, DR; Clark, JK; Cottney, JE; Cowley, PM; Crockatt, M; Evans, L; Feilden, H; Goodwin, RR; Griekspoor, F; Grove, SJ; Houghton, AK; Jones, PS; Morphy, RJ; Smith, AR; Sundaram, H; Vrolijk, D; Weston, MA; Wishart, G; Wren, P Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists. Bioorg Med Chem Lett15:589-93 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50159916 |
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n/a |
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Name | BDBM50159916 |
Synonyms: | 1-[1-(4-Methyl-3-o-tolyloxy-pentyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one | CHEMBL369786 |
Type | Small organic molecule |
Emp. Form. | C25H33N3O2 |
Mol. Mass. | 407.5484 |
SMILES | CC(C)C(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)Oc1ccccc1C |
Structure |
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