| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nociceptin receptor |
|---|
| Ligand | BDBM50159918 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_303722 (CHEMBL829057) |
|---|
| Ki | 38.2±n/a nM |
|---|
| Citation |  Palin, R; Barn, DR; Clark, JK; Cottney, JE; Cowley, PM; Crockatt, M; Evans, L; Feilden, H; Goodwin, RR; Griekspoor, F; Grove, SJ; Houghton, AK; Jones, PS; Morphy, RJ; Smith, AR; Sundaram, H; Vrolijk, D; Weston, MA; Wishart, G; Wren, P Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists. Bioorg Med Chem Lett15:589-93 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nociceptin receptor |
|---|
| Name: | Nociceptin receptor |
|---|
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40702.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41146 |
|---|
| Residue: | 370 |
|---|
| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
|
|
|
|---|
| BDBM50159918 |
|---|
| n/a |
|---|
| Name | BDBM50159918 |
|---|
| Synonyms: | 1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-3-phenyl-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one | CHEMBL182328 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H30ClN3O3 |
|---|
| Mol. Mass. | 492.009 |
|---|
| SMILES | Cc1ccc(Cl)c(OC(C(O)CN2CCC(CC2)n2c3ccccc3[nH]c2=O)c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
