| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM50160148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303296 (CHEMBL827429) |
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| Ki | 0.36±n/a nM |
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| Citation |  Li, MY; Tsai, KC; Xia, L Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett15:657-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 51511.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35348 |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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| BDBM50160148 |
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| n/a |
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| Name | BDBM50160148 |
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| Synonyms: | (S)-4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-3-[3-(3'',4'',5'',6''-tetrahydro-2''H-[2,4'']bipyridinyl-1''-yl)-propylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL182998 | L-771688 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33F2N5O5 |
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| Mol. Mass. | 557.5889 |
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| SMILES | COCC1=C([C@@H](N(C(=O)NCCCN2CCC(CC2)c2ccccn2)C(=O)N1)c1ccc(F)c(F)c1)C(=O)OC |t:3| |
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| Structure | 
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