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TargetInosine-5'-monophosphate dehydrogenase 2
LigandBDBM50160375
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305708 (CHEMBL827223)
IC50 30±n/a nM
Citation Buckley, GMDavies, NDyke, HJGilbert, PJHannah, DRHaughan, AFHunt, CAPitt, WRProfit, RHRay, NCRichard, MDSharpe, ATaylor, AJWhitworth, JMWilliams, SC Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett15:751-4 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine-5'-monophosphate dehydrogenase 2
Name:Inosine-5'-monophosphate dehydrogenase 2
Synonyms:IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:Enzyme
Mol. Mass.:55806.87
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH2 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50160375
n/a
NameBDBM50160375
Synonyms:7-Methoxy-6-oxazol-5-yl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one | CHEMBL180663
TypeSmall organic molecule
Emp. Form.C12H9N3O3S
Mol. Mass.275.283
SMILESCOc1cc2[nH]c(=S)[nH]c(=O)c2cc1-c1cnco1
Structure
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