| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
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| Ligand | BDBM50160843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302481 (CHEMBL827172) |
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| Ki | 1.9±n/a nM |
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| Citation |  Kim, SH; Pudzianowski, AT; Leavitt, KJ; Barbosa, J; McDonnell, PA; Metzler, WJ; Rankin, BM; Liu, R; Vaccaro, W; Pitts, W Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett15:1101-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-9 |
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| Name: | Matrix metalloproteinase-9 |
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| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
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| Type: | Enzyme |
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| Mol. Mass.: | 78452.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14780 |
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| Residue: | 707 |
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| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
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| BDBM50160843 |
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| n/a |
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| Name | BDBM50160843 |
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| Synonyms: | 1-[4-(4-Phenoxy-phenoxy)-phenyl]-1,7,9-triaza-spiro[4.5]decane-2,6,8,10-tetraone | CHEMBL178163 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19N3O6 |
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| Mol. Mass. | 457.4349 |
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| SMILES | O=C1CCC2(N1c1ccc(Oc3ccc(Oc4ccccc4)cc3)cc1)C(=O)NC(=O)NC2=O |
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| Structure | 
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