Ki Summary

Reaction Details

Report a problem with these data

Target

Reverse transcriptase/RNaseH

Ligand

BDBM50160858

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_305018 (CHEMBL829452)

IC50

1700±n/a nM

Citation

Mashino, T; Shimotohno, K; Ikegami, N; Nishikawa, D; Okuda, K; Takahashi, K; Nakamura, S; Mochizuki, M Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. Bioorg Med Chem Lett15:1107-9 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Reverse transcriptase/RNaseH

Name:

Reverse transcriptase/RNaseH

Synonyms:

HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH

Type:

PROTEIN

Mol. Mass.:

65229.15

Organism:

Human immunodeficiency virus 1

Description:

ChEMBL_1473730

Residue:

566

Sequence:

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID

BDBM50160858

n/a

Name

BDBM50160858

Synonyms:

CHEMBL384970 | Fullerene Derivative

Type

Small organic molecule

Emp. Form.

C68H26N2

Mol. Mass.

870.9463

SMILES

C[N+]1(C)C[C@]23[C@H]4[C@@H]5C6=C7c8c4c4C2=C2[C@H]9[C@H]%10c4c-4c8[C@@H]8[C@@H]%11c%12c-4c%10c4c%10c9c9c2c2c%13c%14c(c5c5c6c6c%15c%16c(c%11c%11c%12c4c4c%10c%10c9c%13c9c%12c%14c5c%15c%12c5c%16c%11c4c5c%109)[C@]64C[N+](C)(C)C[C@@]784)[C@@]32C1 |wU:67.94,19.22,14.15,20.50,wD:4.13,6.6,68.99,61.86,5.10,15.28,c:7,t:14,(-4.73,2.21,;-3.99,2.94,;-4.27,3.96,;-2.71,3.74,;-1.44,2.42,;.39,2.73,;1.52,1.26,;2.96,.81,;3.34,1.72,;2.33,3.05,;.89,3.55,;-.61,3.89,;-1.99,3.21,;-3.43,2.65,;-3.6,2.78,;-2.09,3.53,;-.61,4.01,;.81,3.53,;2.34,3.18,;3.6,1.9,;3.09,.92,;1.42,1.35,;.37,2.62,;-1.4,2.49,;-2.13,.95,;-3.48,.28,;-4.21,1.1,;-4.56,.17,;-4.1,1.07,;-3.48,.2,;-3.33,-1.54,;-1.89,-1.97,;-1.16,-.48,;.61,-.36,;1.63,-1.65,;3.01,-.97,;3.65,-1.78,;2.93,-3.28,;2.95,-3.27,;3.71,-1.77,;3.17,-.95,;1.72,-1.54,;.69,-.18,;-1.08,-.38,;-1.81,-1.88,;-3.29,-1.46,;-3.76,-2.42,;-4.38,-1.6,;-3.8,-2.45,;-2.78,-3.78,;-1.3,-4.21,;-.85,-3.31,;.91,-3.15,;1.53,-3.95,;.18,-4.61,;.2,-4.6,;1.56,-3.92,;.96,-3.06,;-.79,-3.23,;-1.27,-4.17,;-2.76,-3.77,;4.16,-.86,;5.06,-1.37,;6.23,-.06,;6.99,-.8,;6.97,.68,;5.09,1.19,;4.09,.89,;-2.14,.84,;-3.45,1.35,)|

Structure