| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-10 |
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| Ligand | BDBM50160974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306079 (CHEMBL833033) |
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| IC50 | 18±n/a nM |
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| Citation |  Han, Y; Giroux, A; Colucci, J; Bayly, CI; Mckay, DJ; Roy, S; Xanthoudakis, S; Vaillancourt, J; Rasper, DM; Tam, J; Tawa, P; Nicholson, DW; Zamboni, RJ Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett15:1173-80 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-10 |
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| Name: | Caspase-10 |
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| Synonyms: | CASP10 | CASPA_HUMAN | MCH4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58956.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92851 |
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| Residue: | 521 |
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| Sequence: | MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT
MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
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| BDBM50160974 |
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| n/a |
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| Name | BDBM50160974 |
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| Synonyms: | CHEMBL366927 | [3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethyl)-amino]-2-oxo-2H-pyrazin-1-yl}-butyrylamino)-4-carboxy-2-oxo-butyl]-hexyl-methyl-ammonium; chloride |
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| Type | Small organic molecule |
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| Emp. Form. | C28H46N7O6 |
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| Mol. Mass. | 576.7076 |
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| SMILES | CCCCCC[NH+](C)CC(=O)C(CC(O)=O)NC(=O)C(CC)n1cc(nc(NCc2nonc2C)c1=O)C(C)(C)C |
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| Structure | 
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