| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, membrane associated |
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| Ligand | BDBM50055366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306495 (CHEMBL828100) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Sawyer, JS; Beight, DW; Smith, EC; Snyder, DW; Chastain, MK; Tielking, RL; Hartley, LW; Carlson, DG Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2. J Med Chem48:893-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2, membrane associated |
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| Name: | Phospholipase A2, membrane associated |
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| Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
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| Type: | Hydrolase |
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| Mol. Mass.: | 16101.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
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| Residue: | 144 |
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| Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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| BDBM50055366 |
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| n/a |
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| Name | BDBM50055366 |
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| Synonyms: | (3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O5 |
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| Mol. Mass. | 380.3939 |
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| SMILES | CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1 |
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| Structure | 
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