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TargetPhospholipase A2, membrane associated
LigandBDBM50161308
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306563 (CHEMBL829138)
IC50 9.0±n/a nM
Citation Sawyer, JSBeight, DWSmith, ECSnyder, DWChastain, MKTielking, RLHartley, LWCarlson, DG Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2. J Med Chem48:893-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phospholipase A2, membrane associated
Name:Phospholipase A2, membrane associated
Synonyms:GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:Hydrolase
Mol. Mass.:16101.20
Organism:Homo sapiens (Human)
Description:The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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  Blast E-value cutoff:
BDBM50161308
n/a
NameBDBM50161308
Synonyms:CHEMBL179118 | [3-Aminooxalyl-1-(2-fluoro-benzyl)-2-methyl-1,2,3,6,7,8-hexahydro-1-aza-as-indacen-4-yloxy]-acetic acid
TypeSmall organic molecule
Emp. Form.C23H21FN2O5
Mol. Mass.424.4216
SMILESCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1F
Structure
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