| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
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| Ligand | BDBM2579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_325080 (CHEMBL860897) |
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| Kd | 0.500000±n/a nM |
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| Citation |  Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol23:329-36 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
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| Name: | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
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| Synonyms: | PHKG | PHKG1 | PHKG1_HUMAN | Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform | Phosphorylase kinase | Phosphorylase kinase gamma subunit 1 | Phosphorylase kinase subunit gamma 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45025.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774515 |
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| Residue: | 387 |
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| Sequence: | MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
KGQQQNRAALFENTPKAVLLSLAEEDY
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| BDBM2579 |
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| n/a |
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| Name | BDBM2579 |
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| Synonyms: | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | CHEMBL388978 | Staurosporin, 4 | Staurosporine | Staurosporine, 8 | US20240002365, Compound staurosporine | US9206188, Staurosporine | US9226923, Staurosporine |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N4O3 |
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| Mol. Mass. | 466.531 |
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| SMILES | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| |
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| Structure | 
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