Ki Summary

Reaction Details

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Target

Calcium/calmodulin-dependent protein kinase kinase 2

Ligand

BDBM50024294

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_325021 (CHEMBL860655)

7500±n/a nM

Citation

Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol23:329-36 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcium/calmodulin-dependent protein kinase kinase 2

Name:

Calcium/calmodulin-dependent protein kinase kinase 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64746.61

Organism:

Homo sapiens (Human)

Description:

gi_27437015

Residue:

588

Sequence:

MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE

BDBM50024294

n/a

Name

BDBM50024294

Synonyms:

SP-600125

Type

Small organic molecule

Emp. Form.

C14H8N2O

Mol. Mass.

220.2261

SMILES

Oc1c2cccc3N=Nc(c23)c2ccccc12 |c:7|

Structure