Ki Summary

Reaction Details

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Target

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Ligand

BDBM21

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_325059 (CHEMBL860795)

9500±n/a nM

Citation

Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol23:329-36 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Name:

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Synonyms:

PHKG2 | PHKG2_HUMAN | Phosphorylase kinase | Phosphorylase kinase gamma subunit 2

Type:

PROTEIN

Mol. Mass.:

46440.15

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774277

Residue:

406

Sequence:

MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG

BDBM21

n/a

Name

BDBM21

Synonyms:

CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine | VANDETANIB | ZD-6474 | ZD6474 | cid_3081361

Type

n/a

Emp. Form.

C22H24BrFN4O2

Mol. Mass.

475.354

SMILES

COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1

Structure