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TargetC-C chemokine receptor type 3
LigandBDBM50161431
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303259 (CHEMBL826385)
Ki 66±n/a nM
Citation Ting, PCLee, JFWu, JUmland, SPAslanian, RCao, JDong, YGarlisi, CGGilbert, EJHuang, YJakway, JKelly, JLiu, ZMcCombie, SShah, HTian, FWan, YShih, NY The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists. Bioorg Med Chem Lett15:1375-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 3
Name:C-C chemokine receptor type 3
Synonyms:C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:Enzyme
Mol. Mass.:41053.88
Organism:Homo sapiens (Human)
Description:P51677
Residue:355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50161431
n/a
NameBDBM50161431
Synonyms:1-[4-(4-Bromo-benzyl)-[1,4'']bipiperidinyl-1''-yl]-2-(2-tert-butyl-phenyl)-ethanone | CHEMBL178576
TypeSmall organic molecule
Emp. Form.C26H33BrN2O
Mol. Mass.469.457
SMILESCc1ccccc1CC(=O)N1CCC(CC1)N1CCC(Cc2ccc(Br)cc2)CC1
Structure
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