| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM50161695 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304261 (CHEMBL829031) |
|---|
| EC50 | 700±n/a nM |
|---|
| Citation |  Castelhano, AL; Dong, H; Fyfe, MC; Gardner, LS; Kamikozawa, Y; Kurabayashi, S; Nawano, M; Ohashi, R; Procter, MJ; Qiu, L; Rasamison, CM; Schofield, KL; Shah, VK; Ueta, K; Williams, GM; Witter, D; Yasuda, K Glucokinase-activating ureas. Bioorg Med Chem Lett15:1501-4 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52101.81 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1279785 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
|
|
|
|---|
| BDBM50161695 |
|---|
| n/a |
|---|
| Name | BDBM50161695 |
|---|
| Synonyms: | 1-(4-Bromo-3-fluoro-phenyl)-3-(5-chloro-thiazol-2-yl)-1-cyclopentylmethyl-urea | CHEMBL541979 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16BrClFN3OS |
|---|
| Mol. Mass. | 432.738 |
|---|
| SMILES | Fc1cc(ccc1Br)N(CC1CCCC1)C(=O)Nc1ncc(Cl)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
