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TargetGonadotropin releasing hormone 1 (GnRHR1)
LigandBDBM50162026
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302845
Ki 0.5±n/a nM
Citation Tucci FCZhu YFStruthers RSGuo ZGross TDRowbottom MWAcevedo OGao YSaunders JXie QReinhart GJLiu XJLing NBonneville AKChen TBozigian HChen C 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J Med Chem 48:1169-78 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin releasing hormone 1 (GnRHR1)
Name:Gonadotropin-releasing hormone receptor
Synonyms:GnRH receptor | GnRH-R | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:Enzyme
Mol. Mass.:37749.45
Organism:Homo sapiens (Human)
Description:P30968
Residue:328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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  Blast E-value cutoff:
BDBM50162026
n/a
NameBDBM50162026
Synonyms:1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-[(S)-2-(methyl-pyridin-2-ylmethyl-amino)-propyl]-1H-pyrimidine-2,4-dione | CHEMBL426780
TypeSmall organic molecule
Emp. Form.C29H29F3N4O3
Mol. Mass.538.5608
SMILESCOc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N(C)Cc2ccccn2)c1=O |wU:26.28,(2.12,4.82,;3.44,4.05,;3.44,2.51,;4.79,1.73,;4.77,.19,;3.44,-.57,;2.12,.2,;2.12,1.74,;.78,2.51,;.78,-.57,;.78,-2.11,;2.12,-2.87,;-.55,-2.87,;-.55,-4.39,;.78,-5.18,;2.12,-4.39,;.78,-3.64,;3.44,-5.16,;3.44,-6.72,;2.12,-7.47,;.78,-6.72,;-.55,-7.47,;-1.87,-2.11,;-3.21,-2.87,;-1.87,-.57,;-3.21,.2,;-3.21,1.74,;-1.88,2.51,;-4.57,2.51,;-5.9,1.74,;-4.57,4.05,;-3.24,4.82,;-1.91,4.04,;-.56,4.82,;-.56,6.35,;-1.93,7.12,;-3.24,6.35,;-.55,.21,;-.55,1.77,)|
Structure
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