| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM50162559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304142 (CHEMBL840258) |
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| EC50 | 291±n/a nM |
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| Citation |  Pinkerton, AB; Cube, RV; Hutchinson, JH; James, JK; Gardner, MF; Rowe, BA; Schaffhauser, H; Rodriguez, DE; Campbell, UC; Daggett, LP; Vernier, JM Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators. Bioorg Med Chem Lett15:1565-71 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 95584.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14416 |
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| Residue: | 872 |
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| Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM50162559 |
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| n/a |
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| Name | BDBM50162559 |
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| Synonyms: | 6,7-Dimethyl-2-propyl-5-[3-(pyridin-4-ylsulfanylmethyl)-benzyloxy]-indan-1-one | CHEMBL180871 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29NO2S |
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| Mol. Mass. | 431.59 |
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| SMILES | CCCC1Cc2cc(OCc3cccc(CSc4ccncc4)c3)c(C)c(C)c2C1=O |
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| Structure | 
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