| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
|---|
| Ligand | BDBM50162772 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305304 (CHEMBL832851) |
|---|
| IC50 | 14.4±n/a nM |
|---|
| Citation |  Mulvihill, MJ; Kan, JL; Beck, P; Bittner, M; Cesario, C; Cooke, A; Keane, DM; Nigro, AI; Nillson, C; Smith, V; Srebernak, M; Sun, FL; Vrkljan, M; Winski, SL; Castelhano, AL; Emerson, D; Gibson, N Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs). Bioorg Med Chem Lett15:1669-73 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 26A1 |
|---|
| Name: | Cytochrome P450 26A1 |
|---|
| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56216.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43174 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
|
|
|
|---|
| BDBM50162772 |
|---|
| n/a |
|---|
| Name | BDBM50162772 |
|---|
| Synonyms: | 3-[6-(2-Dimethylamino-1-imidazol-1-yl-propyl)-naphthalen-2-yloxymethyl]-N,N-dimethyl-benzamide | CHEMBL360072 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32N4O2 |
|---|
| Mol. Mass. | 456.5793 |
|---|
| SMILES | CC(C(c1ccc2cc(OCc3cccc(c3)C(=O)N(C)C)ccc2c1)n1ccnc1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
