| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50162809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305467 (CHEMBL831077) |
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| IC50 | 0.8±n/a nM |
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| Citation |  Tan, Q; Blizzard, TA; Morgan, JD; Birzin, ET; Chan, W; Yang, YT; Pai, LY; Hayes, EC; DaSilva, CA; Warrier, S; Yudkovitz, J; Wilkinson, HA; Sharma, N; Fitzgerald, PM; Li, S; Colwell, L; Fisher, JE; Adamski, S; Reszka, AA; Kimmel, D; DiNinno, F; Rohrer, SP; Freedman, LP; Schaeffer, JM; Hammond, ML Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs. Bioorg Med Chem Lett15:1675-81 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM50162809 |
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| n/a |
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| Name | BDBM50162809 |
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| Synonyms: | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-{4-[2-((R)-3-methyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-chroman-6-ol | CHEMBL361005 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32FNO4 |
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| Mol. Mass. | 477.5671 |
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| SMILES | C[C@@H]1CCN(CCOc2ccc(cc2)[C@@H]2Oc3ccc(O)c(F)c3[C@@H](C)[C@@H]2c2ccc(O)cc2)C1 |
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| Structure | 
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