Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProstaglandin D2 receptor 2
LigandBDBM50162894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_308693 (CHEMBL875722)
Ki 20±n/a nM
Citation Robarge, MJBom, DCTumey, LNVarga, NGleason, ESilver, DSong, JMurphy, SMEkema, GDoucette, CHanniford, DPalmer, MPawlowski, GDanzig, JLoftus, MHunady, KSherf, BAMays, RWStricker-Krongrad, ABrunden, KRHarrington, JJBennani, YL Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists. Bioorg Med Chem Lett15:1749-53 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50162894
n/a
NameBDBM50162894
Synonyms:CHEMBL361972 | [2-(4-Fluoro-benzenesulfonylamino)-6,7,8,9,10,10a-hexahydro-5aH-cyclohepta[b]indol-5-yl]-acetic acid
TypeSmall organic molecule
Emp. Form.C21H23FN2O4S
Mol. Mass.418.482
SMILESOC(=O)CN1C2CCCCCC2c2cc(NS(=O)(=O)c3ccc(F)cc3)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: