| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50137981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303035 (CHEMBL828863) |
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| Ki | 0.43±n/a nM |
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| Citation |  Campiani, G; Butini, S; Fattorusso, C; Trotta, F; Gemma, S; Catalanotti, B; Nacci, V; Fiorini, I; Cagnotto, A; Mereghetti, I; Mennini, T; Minetti, P; Di Cesare, MA; Stasi, MA; Di Serio, S; Ghirardi, O; Tinti, O; Carminati, P Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies. J Med Chem48:1705-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50137981 |
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| n/a |
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| Name | BDBM50137981 |
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| Synonyms: | 7-Chloro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene | CHEMBL426763 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClN3S |
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| Mol. Mass. | 331.863 |
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| SMILES | CN1CCN(CC1)C1=Cn2cccc2Sc2ccc(Cl)cc12 |t:8| |
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| Structure | 
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