| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C beta type |
|---|
| Ligand | BDBM50162997 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305828 (CHEMBL829570) |
|---|
| IC50 | 460±n/a nM |
|---|
| Citation |  Zhang, HC; Derian, CK; McComsey, DF; White, KB; Ye, H; Hecker, LR; Li, J; Addo, MF; Croll, D; Eckardt, AJ; Smith, CE; Li, Q; Cheung, WM; Conway, BR; Emanuel, S; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety. J Med Chem48:1725-8 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C beta type |
|---|
| Name: | Protein kinase C beta type |
|---|
| Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76873.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
|
|---|
| Residue: | 671 |
|---|
| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
|
|
|
|---|
| BDBM50162997 |
|---|
| n/a |
|---|
| Name | BDBM50162997 |
|---|
| Synonyms: | 3-(1H-Indazol-3-yl)-4-(1-pyridin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione | CHEMBL175956 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H15N5O2 |
|---|
| Mol. Mass. | 405.4082 |
|---|
| SMILES | O=C1NC(=O)C(=C1c1cn(-c2cccnc2)c2ccccc12)c1[nH]nc2ccccc12 |c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
