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TargetLiver carboxylesterase 1
LigandBDBM23120
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305509 (CHEMBL831110)
IC50 600±n/a nM
Citation Boger, DLMiyauchi, HDu, WHardouin, CFecik, RACheng, HHwang, IHedrick, MPLeung, DAcevedo, OGuimarães, CRJorgensen, WLCravatt, BF Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J Med Chem48:1849-56 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Liver carboxylesterase 1
Name:Liver carboxylesterase 1
Synonyms:Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1)
Type:Protein
Mol. Mass.:62520.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:567
Sequence:
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
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  Blast E-value cutoff:
BDBM23120
n/a
NameBDBM23120
Synonyms:7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one | CHEMBL177577 | OL-135
TypeSmall organic molecule
Emp. Form.C21H22N2O2
Mol. Mass.334.4116
SMILESO=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Structure
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