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TargetSerine/threonine-protein kinase CHK2
LigandBDBM34064
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305572
IC50 15±n/a nM
Citation Arienti KLBrunmark AAxe FUMcClure KLee ABlevitt JNeff DKHuang LCrawford SPandit CRKarlsson LBreitenbucher JG Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem 48:1873-85 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase CHK2
Name:Serine/threonine-protein kinase Chk1/2
Synonyms:Cds1
Type:Protein
Mol. Mass.:60908.59
Organism:Homo sapiens (Human)
Description:O96017
Residue:543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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  Blast E-value cutoff:
BDBM34064
n/a
NameBDBM34064
Synonyms:2-arylbenzimidazole | CHEMBL179583
TypeSmall organic molecule
Emp. Form.C20H14ClN3O2
Mol. Mass.363.797
SMILESNC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Structure
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