| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
|---|
| Ligand | BDBM50163249 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305572 (CHEMBL874429) |
|---|
| IC50 | 31±n/a nM |
|---|
| Citation |  Arienti, KL; Brunmark, A; Axe, FU; McClure, K; Lee, A; Blevitt, J; Neff, DK; Huang, L; Crawford, S; Pandit, CR; Karlsson, L; Breitenbucher, JG Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem48:1873-85 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk2 |
|---|
| Name: | Serine/threonine-protein kinase Chk2 |
|---|
| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60908.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O96017 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
|
|
|
|---|
| BDBM50163249 |
|---|
| n/a |
|---|
| Name | BDBM50163249 |
|---|
| Synonyms: | 2-[4-(3,4-Dimethoxy-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide | CHEMBL179267 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19N3O4 |
|---|
| Mol. Mass. | 389.404 |
|---|
| SMILES | COc1ccc(Oc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
