| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
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| Ligand | BDBM50163262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305572 (CHEMBL874429) |
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| IC50 | 500±n/a nM |
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| Citation |  Arienti, KL; Brunmark, A; Axe, FU; McClure, K; Lee, A; Blevitt, J; Neff, DK; Huang, L; Crawford, S; Pandit, CR; Karlsson, L; Breitenbucher, JG Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem48:1873-85 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk2 |
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| Name: | Serine/threonine-protein kinase Chk2 |
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| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
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| Type: | Protein |
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| Mol. Mass.: | 60908.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96017 |
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| Residue: | 543 |
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| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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| BDBM50163262 |
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| n/a |
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| Name | BDBM50163262 |
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| Synonyms: | 2-Dibenzofuran-2-yl-1H-benzoimidazole-5-carboxylic acid amide | CHEMBL195648 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13N3O2 |
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| Mol. Mass. | 327.3361 |
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| SMILES | NC(=O)c1ccc2nc([nH]c2c1)-c1ccc2oc3ccccc3c2c1 |
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| Structure | 
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