| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50163634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306838 (CHEMBL831029) |
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| IC50 | 0.010000±n/a nM |
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| Citation |  De Lucca, GV; Kim, UT; Vargo, BJ; Duncia, JV; Santella, JB; Gardner, DS; Zheng, C; Liauw, A; Wang, Z; Emmett, G; Wacker, DA; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Das, AM; Davies, P; Yeleswaram, S; Graden, DM; Solomon, KA; Newton, RC; Trainor, GL; Decicco, CP; Ko, SS Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem48:2194-211 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | CCR3_RAT | Ccr3 | Cmkbr3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41648.91 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1445730 |
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| Residue: | 359 |
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| Sequence: | MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVV
LILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLA
LYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQD
NFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHK
AIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCI
NPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF
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| BDBM50163634 |
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| n/a |
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| Name | BDBM50163634 |
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| Synonyms: | 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea | 1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea | CHEMBL363840 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36FN7O |
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| Mol. Mass. | 505.6301 |
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| SMILES | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 |r| |
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| Structure | 
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