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TargetC-C chemokine receptor type 1
LigandBDBM50163634
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306388
IC50 10000±n/a nM
Citation De Lucca GVKim UTVargo BJDuncia JVSantella JBGardner DSZheng CLiauw AWang ZEmmett GWacker DAWelch PKCovington MStowell NCWadman EADas AMDavies PYeleswaram SGraden DMSolomon KANewton RCTrainor GLDecicco CPKo SS Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem 48:2194-211 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 1
Name:C-C chemokine receptor type 1
Synonyms:C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CD_antigen=CD191 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R
Type:Enzyme
Mol. Mass.:41180.69
Organism:Homo sapiens (Human)
Description:P32246
Residue:355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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  Blast E-value cutoff:
BDBM50163634
n/a
NameBDBM50163634
Synonyms:1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea | 1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea | CHEMBL363840
TypeSmall organic molecule
Emp. Form.C28H36FN7O
Mol. Mass.505.6301
SMILESCn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 |r|
Structure
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