| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50163807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305127 (CHEMBL832423) |
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| IC50 | 0.870000±n/a nM |
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| Citation |  Blagg, JA; Noe, MC; Wolf-Gouveia, LA; Reiter, LA; Laird, ER; Chang, SP; Danley, DE; Downs, JT; Elliott, NC; Eskra, JD; Griffiths, RJ; Hardink, JR; Haugeto, AI; Jones, CS; Liras, JL; Lopresti-Morrow, LL; Mitchell, PG; Pandit, J; Robinson, RP; Subramanyam, C; Vaughn-Bowser, ML; Yocum, SA Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg Med Chem Lett15:1807-10 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50163807 |
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| n/a |
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| Name | BDBM50163807 |
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| Synonyms: | 5-Amino-3-[4-(4-bromo-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | CHEMBL182894 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21BrN2O6 |
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| Mol. Mass. | 477.305 |
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| SMILES | CCOCCC1(Oc2ccc(Oc3ccc(Br)cc3)cc2)C(=O)NC(=O)C(N)C1=O |
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| Structure | 
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