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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50163927
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306060 (CHEMBL874553)
IC50 15000±n/a nM
Citation Raboisson, PMarugán, JJSchubert, CKoblish, HKLu, TZhao, SPlayer, MRMaroney, ACReed, RLHuebert, NDLattanze, JParks, DJCummings, MD Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists. Bioorg Med Chem Lett15:1857-61 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50163927
n/a
NameBDBM50163927
Synonyms:CHEMBL425528 | [(3-Iodo-benzoyl)-(4-trifluoromethyl-benzyl)-amino]-phenyl-acetic acid
TypeSmall organic molecule
Emp. Form.C23H17F3INO3
Mol. Mass.539.2857
SMILESOC(=O)C(N(Cc1ccc(cc1)C(F)(F)F)C(=O)c1cccc(I)c1)c1ccccc1
Structure
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