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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164115 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 3500±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164115 | |||
| n/a | |||
| Name | BDBM50164115 | ||
| Synonyms: | 6-(2,6-Dichloro-3-hydroxymethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL180035 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16Cl2N4O2 | ||
| Mol. Mass. | 427.283 | ||
| SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(CO)c2Cl)c1=O |(.89,-3.84,;.89,-2.31,;-.46,-1.53,;-1.8,-2.32,;-3.13,-1.55,;-4.46,-2.32,;-5.79,-1.56,;-5.79,-.02,;-7.12,.75,;-8.47,-.02,;-8.47,-1.57,;-7.12,-2.32,;-3.13,-.01,;-1.8,.79,;-.46,,;.86,.79,;2.2,.02,;3.53,.79,;4.87,.04,;4.88,-1.52,;6.2,.79,;6.19,2.35,;4.84,3.11,;4.83,4.65,;6.15,5.43,;3.53,2.33,;2.17,3.1,;2.22,-1.53,;3.55,-2.3,)| | ||
| Structure | 
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