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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164117 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 74.0±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164117 | |||
| n/a | |||
| Name | BDBM50164117 | ||
| Synonyms: | 6-(2,6-Dichloro-3-hydroxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181233 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H14Cl2N4O2 | ||
| Mol. Mass. | 413.257 | ||
| SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(O)c2Cl)c1=O |(1.11,-3.66,;1.11,-2.13,;-.25,-1.34,;-1.58,-2.13,;-2.91,-1.34,;-4.25,-2.14,;-5.58,-1.36,;-6.91,-2.14,;-8.25,-1.38,;-8.25,.18,;-6.91,.95,;-5.58,.18,;-2.91,.19,;-1.58,.97,;-.25,.19,;1.08,.97,;2.42,.23,;3.75,.98,;5.08,.23,;5.11,-1.32,;6.41,1,;6.41,2.54,;5.06,3.3,;5.06,4.86,;3.75,2.54,;2.39,3.29,;2.44,-1.34,;3.77,-2.09,)| | ||
| Structure | 
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