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TargetWee1-like protein kinase
LigandBDBM50164123
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304894 (CHEMBL829373)
IC50 550±n/a nM
Citation Palmer, BDSmaill, JBRewcastle, GWDobrusin, EMKraker, AMoore, CWSteinkampf, RWDenny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50164123
n/a
NameBDBM50164123
Synonyms:6-(2-Chloro-phenyl)-2-[4-(2-diethylamino-ethoxy)-phenylamino]-5,8-dimethyl-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181017
TypeSmall organic molecule
Emp. Form.C27H30ClN5O2
Mol. Mass.492.012
SMILESCCN(CC)CCOc1ccc(Nc2ncc3c(C)c(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 |(-10.91,3.89,;-9.58,4.67,;-8.25,3.89,;-6.91,4.67,;-5.57,3.91,;-8.23,2.36,;-6.9,1.6,;-6.9,.06,;-5.57,-.71,;-5.54,-2.27,;-4.21,-3.02,;-2.91,-2.24,;-1.56,-3.02,;-.23,-2.24,;-.23,-.68,;1.1,.09,;2.43,-.68,;3.76,.09,;3.74,1.63,;5.09,-.68,;6.42,.11,;7.75,-.66,;9.08,.12,;9.08,1.65,;7.73,2.42,;6.4,1.63,;5.07,2.28,;5.09,-2.22,;6.45,-2.99,;3.76,-2.99,;3.76,-4.55,;2.43,-2.24,;1.1,-3.02,;-2.89,-.71,;-4.24,.07,)|
Structure
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