Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50164123 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | 550±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50164123 | |||
n/a | |||
Name | BDBM50164123 | ||
Synonyms: | 6-(2-Chloro-phenyl)-2-[4-(2-diethylamino-ethoxy)-phenylamino]-5,8-dimethyl-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181017 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30ClN5O2 | ||
Mol. Mass. | 492.012 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3c(C)c(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 |(-10.91,3.89,;-9.58,4.67,;-8.25,3.89,;-6.91,4.67,;-5.57,3.91,;-8.23,2.36,;-6.9,1.6,;-6.9,.06,;-5.57,-.71,;-5.54,-2.27,;-4.21,-3.02,;-2.91,-2.24,;-1.56,-3.02,;-.23,-2.24,;-.23,-.68,;1.1,.09,;2.43,-.68,;3.76,.09,;3.74,1.63,;5.09,-.68,;6.42,.11,;7.75,-.66,;9.08,.12,;9.08,1.65,;7.73,2.42,;6.4,1.63,;5.07,2.28,;5.09,-2.22,;6.45,-2.99,;3.76,-2.99,;3.76,-4.55,;2.43,-2.24,;1.1,-3.02,;-2.89,-.71,;-4.24,.07,)| | ||
Structure |