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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164133 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | >50000±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164133 | |||
| n/a | |||
| Name | BDBM50164133 | ||
| Synonyms: | 6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL361574 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H18Cl2N4O3 | ||
| Mol. Mass. | 457.309 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(5.67,5.48,;4.32,4.71,;4.36,3.15,;5.7,2.4,;5.7,.86,;7.05,.11,;7.05,-1.45,;4.37,.09,;4.37,-1.45,;3.04,.86,;3.02,2.37,;1.69,3.14,;1.71,.06,;.38,.83,;-.93,.05,;-2.28,.83,;-3.61,.04,;-3.61,-1.5,;-4.94,-2.27,;-6.28,-1.52,;-6.27,.04,;-7.62,.79,;-8.95,.04,;-8.93,-1.52,;-7.6,-2.27,;-2.28,-2.27,;-.93,-1.49,;.38,-2.26,;.38,-3.8,;1.71,-1.49,;3.06,-2.25,)| | ||
| Structure | 
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